vineri, 27 martie 2009
marți, 24 martie 2009
joi, 19 martie 2009
urmatoarea carte a lui Lyle McDonald
Chapter 2: Why you are the source of all of your problems
Chapter 3: Eat right, exercise and die anyway
Chapter 4: Chicks don't dig abs, chicks dig cold hard fucking cash
miercuri, 18 martie 2009
luni, 16 martie 2009
vineri, 13 martie 2009
joi, 12 martie 2009
cateva mituri facute praf
marți, 10 martie 2009
for the low carb fanatics - de pe un forum
Like most low carb fanatics who are ignorant of all but the most pop-physiology, you’re incorrect to think that fat balance is all about insulin. You need to understand that there are a multitude of enzymes that are involved in triacylglycerol synthesis and lipolysis. “Insulin” is not a pathway. It’s one of several hormones that have an effect on the enzymes that comprise the actual pathways. What enzymes am I talking about? For fatty acid uptake, there’s FAT/CD36, FATP-1 to -6, and FABPpm. For fatty acid synthesis, there’s fatty acid synthase. For glucose uptake, there’s Glut1 and Glut4. For esterfication, there’s GPAT, PAP1, and DGAT1 and DGAT2. For lipolysis, there’s HSL, perilipin, and Protein kinase A. What “regulates all this?” It’s definitely not just “insulin”. That’s an incredibly simplistic, insulinocentric view. You know what else has an effect on these lipogenic/lipolytic enzymes besides insulin? There’s angiotensin II, the adrenergic receptor (catacholamines), FoxC2, PTP1B, and last but not least ASP. ASP stimulates triacylglycerol synthesis more than any other known adipose tissue factor. It’s also a potent stimulator of glucose transport [PMID: 9130021]. It works independently of insulin, through a different signaling pathway. It effectively synthesizes triacylglycerol even in the absence of glucose and insulin [PMID: 8492712]. Finally, guess what the primary regulator of ASP production is? Dietary fat (packaged as chylomicrons) [PMID: 9694837]. Fat intake and ASP will lead to a positive fat balance just as much as carb intake and insulin will. Which is why it’s all about calories. Unfortunately, low carb nuts never look past insulin. They ignore (or are ignorant of) the fact that fat stores itself with tremendous efficiency without any insulin whatsoever. Take a look at the broader picture. Fatty acids are taken up into adipocytes via facilitated diffusion, mediated by fatty acid transporters like the ones I mentioned above. You don’t need insulin for this. Dietary FFAs will diffuse into adipocytes down the concentration gradient. There may even be passive diffusion. You then need a triacylglycerol backbone and the acylation (esterfication) steps that lead to the production of a triacylglycerol. ASP can stimulate both. After all, it’s called “acylation-stimulating protein.” This process works just fine with basal levels of insulin or glucose. And as explained before, ASP is produced in response to FAT INTAKE. Weight loss is all about negative calorie balance, not lowering of insulin. Research clearly shows that when isonitrogenous diets are compared, higher carb diets (with higher insulin levels) do JUST AS WELL as lower carb diets at reducing bodyfat. While low carb diets have lower insulin levels, they have higher ASP levels. And vice versa with a low fat diet. Why? Because carb intake (or type) and insulin levels are absolutely unable to account for fat loss. It’s all about energy balance. |
luni, 9 martie 2009
cardio
berea e sanatoasa
Melatonin present in beer contributes to increase the levels of melatonin and antioxidant capacity of the human serum.
Maldonado MD, Moreno H, Calvo JR.
Department Medical Biochemistry and Molecular Biology, University of Seville Medical School, Avda. Sánchez Pizjuán 4, 41009 Seville, Spain.
BACKGROUND & AIM: Melatonin is a molecule with antioxidative properties including direct free radical scavenging and indirect stimulatory actions on a variety of antioxidative enzymes which further promote its ability to reduce the toxicity of radicals and their associated reactants. Beer is an integral element of the diet of numerous people and is rich in antioxidants. We analyzed if melatonin is present in beer and if so, at what concentration. It further determines whether the moderate consumption of beer has an effect on the total antioxidant status (TAS) of human serum. METHODS: We analyzed 18 brands of beer with different percentage of alcohol content in order to determine the concentration of melatonin. Serum samples were collected from 7 healthy volunteers. These samples were used to measure melatonin and TAS on basal conditions and after drinking beer. RESULTS: Showed that all the beer analyzed did indeed contain melatonin and the more they have got, the greater was its degree of alcohol. Both melatonin and TAS in human serum increased after drinking beer. CONCLUSIONS: Melatonin present in the beer does contribute to the total antioxidative capability of human serum and moderate beer consumption can protect organism from overall oxidative stress.
vineri, 6 martie 2009
miercuri, 4 martie 2009
(de) constructing computer guy
luni, 2 martie 2009
orthorexia nervosa
The act of eating pure food begins to carry pseudospiritual connotations. As orthorexia progresses, a day filled with sprouts, umeboshi plums, and amaranth biscuits comes to feel as holy as one spent serving the poor and homeless. When an orthorexic slips up (which may involve anything from devouring a single raisin to consuming a gallon of Haagen Dazs ice cream and a large pizza), he experiences a fall from grace and must perform numerous acts of penitence. These usually involve ever-stricter diets
This "kitchen spirituality" eventually reaches a point where the sufferer spends most of his time planning, purchasing, and eating meals. The orthorexic's inner life becomes dominated by efforts to resist temptation, self-