miercuri, 27 mai 2009

carbohidrati/cancer

din ce in ce mai multe studii confirma ca o dieta ketogenica este de preferat pentru cei bolnavi de cancer. o explicatie sumara mai jos...

"Unlike healthy cells, which generate energy by metabolizing sugar in their mitochondria, cancer cells appeared to fuel themselves exclusively through glycolysis, a less-efficient means of creating energy through the fermentation of sugar in the cytoplasm. The theory is simple: If most aggressive cancers rely on the fermentation of sugar for growing and dividing, then take away the sugar and they should stop spreading. Meanwhile, normal body and brain cells should be able to handle the sugar starvation; they can switch to generating energy from fatty molecules called ketone bodies — the body's main source of energy on a fat-rich diet — an ability that some or most fast-growing and invasive cancers seem to lack."

marți, 12 mai 2009

harvard info

1\ Putting the joie de vivre back into health, Part 1

Lately, health researchers are reporting that maybe we can have our health and enjoy ourselves, too. Studies have elevated coffee to health-drink status by linking it to a reduced risk of dementia and Parkinson’s disease. Dozens of findings have shown that alcohol and chocolate may have cardiac benefits. Here is a rundown of research showing how to enjoy and be healthy — in that order!

Alcohol

Drinking increases “good” HDL cholesterol, reduces factors in blood that make it more likely to clot, and may directly affect blood vessels, keeping the linings smooth and pliable and thus less vulnerable to atherosclerosis. European researchers reported interesting findings in 2008 that show a connection between alcohol intake and higher blood levels of omega-3 fats. Indeed, temperate tippling has been associated with everything from greater bone density to less risk for Alzheimer’s disease and vascular dementia, as well as protection against heart disease and stroke.

Moderation is paramount when it comes to alcohol, because drinking too much is patently ruinous. Triglycerides and blood pressure go up. Binge drinking can lead to stroke. Moderation is flexibly defined, but the American Heart Association guidelines are often cited: for men, one to two drinks a day; for women, just one. A drink is defined as a 12-ounce beer, 4 ounces of wine, or 1.5 ounces of 80-proof liquor.

Women do need to worry about alcohol increasing breast cancer risk. Alcohol may drive up estrogen levels, and estrogen seems to play an integral part in the development of many breast cancers. However, at moderate amounts (the drink-a-day level), the risk is small. Folic acid may help offset the breast cancer risk posed by alcohol, so women who drink are encouraged to get an extra 400 micrograms per day.

Chocolate

A steady stream of studies has shown chocolate improves blood flow through arteries that supply the heart and the brain. In 2008, Harvard researchers found that two weeks of enhanced chocolate intake quickened blood flow through the middle cerebral artery. And Italian researchers reported a possible connection between eating dark chocolate and low levels of C-reactive protein, a marker for inflammation.

The chocolate-as-healthful dream does need a couple of reality checks. The most likely explanation for chocolate’s good effects is that cocoa beans contain substances called flavonols (specifically, catechin and epicatechin, which are also found in tea) that stimulate production of nitric oxide, a chemical that relaxes blood vessels. In the studies cited above, researchers have used “flavonol-rich” chocolate. Dark chocolate may have more flavonols than other types, but you can’t go just by darkness. Some companies have started to market products advertised as preserving the cocoa bean’s flavonol content.

Another caveat: the sugar and fat content of chocolate candy translates into calories (over 200 in a 3.5-ounce bar of expensive dark chocolate). And some of the fat in many chocolate bars is the unhealthful saturated variety.

Coffee

For the health conscious, a cup of coffee was once a somewhat perilous pleasure. Early studies showed a connection between coffee and heart attack, a worry that seemed to be validated by coffee’s ability to quicken the pulse. Some other studies cast the gloomy shadow of cancer risk.

But the cancer research was flawed or overturned by more definitive findings. Meanwhile, the coffee–cardiovascular disease research has done an about-face: now the gist is that coffee drinkers seem to be less likely to have heart attacks and strokes and develop diabetes than nondrinkers.

Study results indicate that coffee drinking may tamp down the risk of developing Parkinson’s disease. No one is sure why, although it’s been suggested that caffeine affects receptors in the basal ganglia, the part of the brain most damaged in Parkinson’s. Other studies are brewing hopes that coffee may affect our brain cells in ways that diminish risk for dementia and Alzheimer’s disease.

Coffee does still come with cautionary notes. Pregnant women are still advised to limit, if not avoid, caffeine intake. Another caution: unfiltered coffee — which includes coffee drinks made with espresso — may increase “bad” LDL levels because some harmful substances in the coffee don’t get filtered out. There’s nothing wrong with the occasional latte or cappuccino, but overdoing it may mean a return to the bad old days when coffee was cardiovascularly suspect.

For more information on nutrition and health, order our Special Health Report, Healthy Eating: A guide to the new nutrition, at www.health.harvard.edu/HE.