luni, 21 martie 2011
vineri, 18 martie 2011
postul religios e sanatos
A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women
Richard J Bloomer, Mohammad M Kabir, John F Trepanowski, Robert E Canale and Tyler M Farney
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Nutrition & Metabolism 2011, 8:17 doi:10.1186/1743-7075-8-17
Published: 18 March 2011
Abstract (provisional)
Background
Dietary modification via both caloric and nutrient restriction is associated with multiple health benefits, some of which are related to an improvement in antioxidant status and a decrease in the production of reactive oxygen species. The Daniel Fast is based on the Biblical book of Daniel, is commonly partaken for 21 days, and involves food intake in accordance with a stringent vegan diet. The purpose of the present study was to determine the effect of a 21 day Daniel Fast on biomarkers of antioxidant status and oxidative stress. Methods: 43 subjects (13 men; 30 women; 35+/-1 yrs; range: 20-62 yrs) completed a 21 day Daniel Fast following the guidelines provided by investigators. Subjects reported to the lab in a 12 hour post-absorptive state both pre fast (day 1) and post fast (day 22). At each visit, blood was collected for determination of malondialdehyde (MDA), hydrogen peroxide (H2O2), nitrate/nitrite (NOx), Trolox Equivalent Antioxidant Capacity (TEAC), and Oxygen Radical Absorbance Capacity (ORAC). Subjects recorded dietary intake during the 7 day period immediately prior to the fast and during the final 7 days of the fast. Results: A decrease was noted in MDA (0.66+/-0.03 vs. 0.56+/-0.02 umol/L; p=0.004), while H2O2 demonstrated a trend for lowering (4.42+/-0.32 vs. 3.78+/-0.21 umol/L; p=0.074). Both NOx (18.79+/-1.92 vs. 26.97+/-2.40 umol/L; p=0.003) and TEAC (0.47+/-0.01 vs. 0.51+/-0.01 mmol/L; p=0.001) increased from pre to post fast, while ORAC was unchanged (5243+/-103 vs. 5249+/-183 umol/L TE; p=0.974). As expected, multiple differences in dietary intake were noted (p<0.05), including a reduction in total calorie intake (2185+/-94 vs. 1722+/-85). Conclusion: Modification of dietary intake in accordance with the Daniel Fast is associated with an improvement in selected biomarkers of antioxidant status and oxidative stress, including metabolites of nitric oxide (i.e., NOx).
Richard J Bloomer, Mohammad M Kabir, John F Trepanowski, Robert E Canale and Tyler M Farney
For all author emails, please log on.
Nutrition & Metabolism 2011, 8:17 doi:10.1186/1743-7075-8-17
Published: 18 March 2011
Abstract (provisional)
Background
Dietary modification via both caloric and nutrient restriction is associated with multiple health benefits, some of which are related to an improvement in antioxidant status and a decrease in the production of reactive oxygen species. The Daniel Fast is based on the Biblical book of Daniel, is commonly partaken for 21 days, and involves food intake in accordance with a stringent vegan diet. The purpose of the present study was to determine the effect of a 21 day Daniel Fast on biomarkers of antioxidant status and oxidative stress. Methods: 43 subjects (13 men; 30 women; 35+/-1 yrs; range: 20-62 yrs) completed a 21 day Daniel Fast following the guidelines provided by investigators. Subjects reported to the lab in a 12 hour post-absorptive state both pre fast (day 1) and post fast (day 22). At each visit, blood was collected for determination of malondialdehyde (MDA), hydrogen peroxide (H2O2), nitrate/nitrite (NOx), Trolox Equivalent Antioxidant Capacity (TEAC), and Oxygen Radical Absorbance Capacity (ORAC). Subjects recorded dietary intake during the 7 day period immediately prior to the fast and during the final 7 days of the fast. Results: A decrease was noted in MDA (0.66+/-0.03 vs. 0.56+/-0.02 umol/L; p=0.004), while H2O2 demonstrated a trend for lowering (4.42+/-0.32 vs. 3.78+/-0.21 umol/L; p=0.074). Both NOx (18.79+/-1.92 vs. 26.97+/-2.40 umol/L; p=0.003) and TEAC (0.47+/-0.01 vs. 0.51+/-0.01 mmol/L; p=0.001) increased from pre to post fast, while ORAC was unchanged (5243+/-103 vs. 5249+/-183 umol/L TE; p=0.974). As expected, multiple differences in dietary intake were noted (p<0.05), including a reduction in total calorie intake (2185+/-94 vs. 1722+/-85). Conclusion: Modification of dietary intake in accordance with the Daniel Fast is associated with an improvement in selected biomarkers of antioxidant status and oxidative stress, including metabolites of nitric oxide (i.e., NOx).
vineri, 11 martie 2011
luni, 7 martie 2011
radicali liberi
ce sa vezi, nu sunt asa rai
"As usual, it's a case of everything in moderation. In normal conditions, free radicals act as important signal substances, but very high levels or long-lasting increases can lead to disease"
"As usual, it's a case of everything in moderation. In normal conditions, free radicals act as important signal substances, but very high levels or long-lasting increases can lead to disease"
vineri, 4 martie 2011
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