eSERBAN

Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

2011-11-01T09:29:00.001-07:00

Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

Rainer J Klement and Ulrike Kammerer

Nutrition & Metabolism 2011, 8:75 doi:10.1186/1743-7075-8-75

Published: 26 October 2011

Abstract

Over the last years, evidence has accumulated suggesting that by systematically reducing the amount of dietary carbohydrates (CHOs) one could suppress, or at least delay, the emergence of cancer, and that proliferation of already existing tumor cells could be slowed down. This hypothesis is supported by the association between modern chronic diseases like the metabolic syndrome and the risk of developing or dying from cancer. CHOs or glucose, to which more complex carbohydrates are ultimately digested, can have direct and indirect effects on tumor cell proliferation: first, contrary to normal cells, most malignant cells depend on steady glucose availability in the blood for their energy and biomass generating demands and are not able to metabolize significant amounts of fatty acids or ketone bodies due to mitochondrial dysfunction. Second, high insulin and insulin-like growth factor (IGF)-1 levels resulting from chronic ingestion of CHO-rich Western diet meals can directly promote tumor cell proliferation via the insulin/IGF-1 signaling pathway. Third, ketone bodies that are elevated when insulin and blood glucose levels are low, have been found to negatively affect proliferation of different malignant cells in vitro or not to be usable by tumor cells for metabolic demands, and a multitude of mouse models have shown anti-tumorigenic properties of very low-CHO ketogenic diets. In addition, many cancer patients exhibit an altered glucose metabolim characterized by insulin resistance and may profit from an increased protein and fat intake. In this review, we address the possible beneficial effects of low CHO diets on cancer prevention and treatment. Emphasis will be placed on the role of insulin and IGF-1 signaling in tumorigenesis as well as altered dietary needs of cancer patients.

Conclusions

We summarize our main findings from the literature regarding the role of dietary CHO

restriction in cancer development and outcome.

(i) Most, if not all, tumor cells have a high demand on glucose compared to benign

cells of the same tissue and conduct glycolysis even in the presence of oxygen (the

Warburg effect). In addition, many cancer cells express insulin receptors (IRs) and

show hyperactivation of the IGF1R-IR pathway. Evidence exists that chronically

elevated blood glucose, insulin and IGF1 levels facilitate tumorigenesis and

worsen the outcome in cancer patients.

(ii) The involvement of the glucose-insulin axis may also explain the association of

the metabolic syndrome with an increased risk for several cancers. CHO restriction

has already been shown to exert favorable effects in patients with the metabolicsyndrome. Epidemiological and anthropological studies indicate that restricting

dietary CHOs could be beneficial in decreasing cancer risk.

(iii) Many cancer patients, in particular those with advanced stages of the disease,

exhibit altered whole-body metabolism marked by increased plasma levels of

inflammatory molecules, impaired glycogen synthesis, increased proteolysis and

increased fat utilization in muscle tissue, increased lipolysis in adipose tissue and

increased gluconeogenesis by the liver. High fat, low CHO diets aim at accounting

for these metabolic alterations. Studies conducted so far have shown that such

diets are safe and likely beneficial, in particular for advanced stage cancer patients.

(iv) CHO restriction mimics the metabolic state of calorie restriction or – in the case of

KDs – fasting. The beneficial effects of calorie restriction and fasting on cancer

risk and progression are well established. CHO restriction thus opens the

possibility to target the same underlying mechanisms without the side-effects of

hunger and weight loss.

(v) Some laboratory studies indicate a direct anti-tumor potential of ketone bodies.

During the past years, a multitude of mouse studies indeed proved anti-tumor

effects of KDs for various tumor types, and a few case reports and pre-clinical

studies obtained promising results in cancer patients as well. Several registered

clinical trials are going to investigate the case for a KD as a supportive therapeutic

option in oncology.

Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: A summary of available findings

2011-10-10T04:38:00.000-07:00

Impact of caloric and dietary restriction regimens on markers of health and

longevity in humans and animals: A summary of available findings

Nutrition Journal 2011, 10:107 doi:10.1186/1475-2891-10-107

John F Trepanowski (jtrepa2@uic.edu)

Robert E Canale (rcanale@memphis.edu)

Kate E Marshall (kmarsh14@uthsc.edu)

Mohammad M Kabir (mkabir@memphis.edu)

Richard J Bloomer (rbloomer@memphis.edu)

ISSN 1475-2891

Article type Review

Submission date 23 June 2011

Acceptance date 7 October 2011

Publication date 7 October 2011

Article URL http://www.nutritionj.com/content/10/1/107

OVERALL SUMMARY AND CONCLUSIONS

CR has been demonstrated to extend the maximal lifespan of a diverse group of species. 24

This extension of life is maximized when: 1) the magnitude of CR is elevated to the highest

possible value before inducing malnutrition and 2) the duration of CR is maximized. Animals on

CR regimens exhibit a variety of improvements in overall health in general and cardiovascular

health in particular. Unfortunately, the likelihood of discovering whether or not CR extends

human life is rather remote due to the ethical and logistical limitations of research design. The

optimal magnitude and duration of CR for humans will also likely never be known for the same

reason. Nonetheless, many human CR studies have noted favorable changes in biomarkers

related to cardiovascular and glucoregulatory function, which likely relate to quality of life and

may relate to longevity.

Due to the austerity of following a CR regimen of sufficient magnitude and duration,

alternatives such as CE, ADF, and DR may prove to be more appealing. The most pertinent

consideration to make when evaluating these alternatives is whether or not they elicit benefits

that are comparable to CR. ADF has been demonstrated to extend life and improve both

cardiovascular and glucoregulatory funnction in animals. Human trials have noted heterogeneous

findings and sex-specific differences regarding ADF’s effects on glucoregulatory function.

Unfortunately, it is difficult to compare the effects of ADF and CR regimens across different

studies due to an enormous number of confounding variables. Future studies should feature an

ADF group and a CR group so that direct comparisons can be made. Regarding DR, neither

carbohydrate restriction nor lipid restriction extend life. However, protein restriction appears to

extend maximum lifespan by 20%. Recent findings suggest that methionine restriction may be

the single cause of life extension observed in protein restriction studies. Future studies should

examine the effects of different magnitudes of methionine restriction on life extension.

As noted above, considerable research has recently focused on whether CE augments any 25

of the health-promoting benefits caused by CR alone. Very few conclusions can currently be

made due to the mixed results of the studies. CE does not appear to extend life beyond any

extension observed to be caused by CR. However, CE may be more manageable for many

individuals due to the smaller reduction in dietary calorie consumption. Future work in this area

should examine different exercise intensities, volumes, frequencies, and modalities.

Also, future work should compare different amounts of exercise-induced caloric expenditure.

Islamic Ramadan, the three principal fasting periods of Greek Orthodox Christianity, and

the Daniel Fast each provide a unique and interesting vantage point for evaluating the effects of

food restriction/modification. The majority of findings related to Ramadan fasting are mixed,

and these discrepancies are most likely due to the differences in cultural norms – particularly

dietary norms – of the groups studied. The three Greek Orthodox Christian fasts appear to

decrease body mass and lower both total and LDL cholesterol levels, although these fasts

minimally affect the intake of most vitamins and minerals. Finally, the Daniel Fast is associated

with profound and favorable effects on a variety of markers related to human health, including

blood pressure, blood lipids, insulin sensitivity, and biomarkers of oxidative stress.

This paper has touched on some of the numerous methods of restricting dietary intake.

Whether one chooses to restrict energy intake daily, fast every other day, restrict intake of a

particular macronutrient, or fast for religious purposes, the authors hope that this paper can serve as a valuable tool to understanding the ability of dietary modification to improve overall health and the quality of life. Furthermore, we hope that this information will fuel the development of new ideas and research studies focused on investigating the health benefits of caloric and dietary

restriction.

Abbreviations: ADF, alternate-day fasting; ASUI, Asthma Symptom Utility Index; BDNF,

brain-derived neurotrophic factor; CALERIE, Comprehensive Assessment of Long Term Effects

of Reducing Caloric Intake; CE, caloric restriction combined with exercise; CR, caloric

restriction; DR, dietary restriction; FEV1, forced expiratory volume; HDL, high density

lipoprotein; LDL, low density lipoprotein; MDA, malondialdehyde; MI, myocardial infarction;

mini-AQLQ, mini-Asthma Quality of Life Questionnaire; PEF, Peak Expiratory Flow

nu din cauza insulinei esti gras

2011-09-23T00:12:00.000-07:00

un post interesant aici

Brad Pilon - un articol interesant

2011-07-26T23:58:00.000-07:00

aici

Bill de Simone

2011-06-29T23:08:00.000-07:00

http://youtu.be/e34h3VIjEj4

Human Biological Clock

2011-06-27T00:17:00.000-07:00

aici

studiu nou despre post

2011-04-26T23:43:00.001-07:00

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients.

The dietary recommendation for cancer patients receiving chemotherapy, as described by the American Cancer Society, is to increase calorie and protein intake. Yet, in simple organisms, mice, and humans, fasting-no calorie intake-induces a wide range of changes associated with cellular protection, which would be difficult to achieve even with a cocktail of potent drugs. In mammals, the protective effect of fasting is mediated, in part, by an over 50% reduction in glucose and insulin-like growth factor 1 (IGF-I) levels. Because proto-oncogenes function as key negative regulators of the protective changes induced by fasting, cells expressing oncogenes, and therefore the great majority of cancer cells, should not respond to the protective signals generated by fasting, promoting the differential protection (differential stress resistance) of normal and cancer cells. Preliminary reports indicate that fasting for up to 5 days followed by a normal diet, may also protect patients against chemotherapy without causing chronic weight loss. By contrast, the long-term 20 to 40% restriction in calorie intake (dietary restriction, DR), whose effects on cancer progression have been studied extensively for decades, requires weeks-months to be effective, causes much more modest changes in glucose and/or IGF-I levels, and promotes chronic weight loss in both rodents and humans. In this study, we review the basic as well as clinical studies on fasting, cellular protection and chemotherapy resistance, and compare them to those on DR and cancer treatment. Although additional pre-clinical and clinical studies are necessary, fasting has the potential to be translated into effective clinical interventions for the protection of patients and the improvement of therapeutic index.Oncogene advance online publication, 25 April 2011

1861 US ARMY dietary guidlines

2011-04-11T00:48:00.000-07:00

Soldiers should be fed a mixed diet of animal and vegetable substances.

A variety of foods are needed to avoid monotony and increase assimilation.

A healthy diet must conform to the physiological requirements of the season with less animal fats in the summer dietary, and more starch, vegetables, and fruits.

Fresh fruits are always preferable to dry or preserved ones.

Farinaceous vegetables are more nourishing than roots or grasses.

The best soldiers in the world are fed on dark colored bread.

French army dietaries provide nutritious soups made with meat or vegetables.

The woody fibre of the vegetable provides bulk as well as nourishment.

Each company should have at least one educated cook.

Beans, unless thoroughly cooked, are only fit for horses. When half-cooked, they will provoke indigestion and diarrhea.

Ardent spirits are not necessary for health and the soldier is better off without them.

Soldiers must be well fed to bear the fatigues of marching, to encounter unaffected the changes of climate, and to develop a high muscular tone.

ISSN position on meal frequency

2011-04-04T22:11:00.000-07:00

critica pe blogul leangains

DNA

2011-03-21T01:01:00.001-07:00

aici

postul religios e sanatos

2011-03-18T08:16:00.001-07:00

A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women
Richard J Bloomer, Mohammad M Kabir, John F Trepanowski, Robert E Canale and Tyler M Farney
For all author emails, please log on.
Nutrition & Metabolism 2011, 8:17 doi:10.1186/1743-7075-8-17
Published: 18 March 2011
Abstract (provisional)
Background
Dietary modification via both caloric and nutrient restriction is associated with multiple health benefits, some of which are related to an improvement in antioxidant status and a decrease in the production of reactive oxygen species. The Daniel Fast is based on the Biblical book of Daniel, is commonly partaken for 21 days, and involves food intake in accordance with a stringent vegan diet. The purpose of the present study was to determine the effect of a 21 day Daniel Fast on biomarkers of antioxidant status and oxidative stress. Methods: 43 subjects (13 men; 30 women; 35+/-1 yrs; range: 20-62 yrs) completed a 21 day Daniel Fast following the guidelines provided by investigators. Subjects reported to the lab in a 12 hour post-absorptive state both pre fast (day 1) and post fast (day 22). At each visit, blood was collected for determination of malondialdehyde (MDA), hydrogen peroxide (H2O2), nitrate/nitrite (NOx), Trolox Equivalent Antioxidant Capacity (TEAC), and Oxygen Radical Absorbance Capacity (ORAC). Subjects recorded dietary intake during the 7 day period immediately prior to the fast and during the final 7 days of the fast. Results: A decrease was noted in MDA (0.66+/-0.03 vs. 0.56+/-0.02 umol/L; p=0.004), while H2O2 demonstrated a trend for lowering (4.42+/-0.32 vs. 3.78+/-0.21 umol/L; p=0.074). Both NOx (18.79+/-1.92 vs. 26.97+/-2.40 umol/L; p=0.003) and TEAC (0.47+/-0.01 vs. 0.51+/-0.01 mmol/L; p=0.001) increased from pre to post fast, while ORAC was unchanged (5243+/-103 vs. 5249+/-183 umol/L TE; p=0.974). As expected, multiple differences in dietary intake were noted (p<0.05), including a reduction in total calorie intake (2185+/-94 vs. 1722+/-85). Conclusion: Modification of dietary intake in accordance with the Daniel Fast is associated with an improvement in selected biomarkers of antioxidant status and oxidative stress, including metabolites of nitric oxide (i.e., NOx).

slabirea este independenta de insulina

2011-03-11T07:21:00.000-08:00

un post interesant aici

Cristi, ai citit?

radicali liberi

2011-03-07T01:13:00.001-08:00

ce sa vezi, nu sunt asa rai

"As usual, it's a case of everything in moderation. In normal conditions, free radicals act as important signal substances, but very high levels or long-lasting increases can lead to disease"

Brad Pilon inflamation theory

2011-03-04T00:11:00.000-08:00

aici

vrei sa slabesti? poti sa mananci ORICE

2011-02-24T02:58:00.001-08:00

AICI

"Eat less, while enjoying the foods you eat. Eat lots of fruits and vegetables, and lots of herbs and spices. And maybe most importantly, spend less time stressing over the types of food you are eating."

mecinicumilmaicheama

2011-02-14T01:53:00.000-08:00

tataie e depasit saracu...citat din evz

"Răcoritoarele "light" au fost intens promovate. Toţi cei aflaţi în lupta cu kilogramele erau consolaţi că, printre atâtea restricţii, puteau să simtă gustul de zahăr fără "vina" că se va şi depune. Cine crede că băuturile dietetice nu îngraşă se înşală însă: în final, se vor îngrăşa mai mult, pentru că vor compensa mâncând mai mult din alte alimente.

"Nu poţi păcăli organismul: el va reţine caloriile pe care nu le-a primit din băuturile fals-dulci din alte surse. Tot metabolismul se dereglează", atrage atenţia specialistul Mencinicopschi."

American Dietary Guidlines for 2010

2011-02-07T09:16:00.000-08:00

aici

low carb my ass

2010-12-06T00:36:00.001-08:00

un post misto

despre celulita

2010-11-30T07:40:00.000-08:00

interesant

insulin

2010-11-18T23:14:00.000-08:00

not so bad after all

twinkie diet

2010-11-10T12:48:00.001-08:00

oh yeah

post intermitent (fasting)

2010-10-21T20:58:00.001-07:00

10 mituri

insulin

2010-10-16T23:51:00.000-07:00

ultima parte dintr-o serie de articole interesante despre insulina aici

The bottom line is that insulin does not deserve the bad reputation that it has been given, and the “carbohydrates drive insulin which drives fat storage” mantra is wrong. To summarize:

Insulin suppresses appetite; it does not increase it
A high carbohydrate diet does not cause chronically high insulin levels
Protein is insulinemic, and in certain cases, can be just as insulinemic as carbohydrate
Contrary to popular belief, glucagon does not “cancel out” the suppression of lipolysis by insulin when protein is ingested
The insulinemic effects of protein are due to a direct stimulatory effect on the pancreas, and not because the protein is converted to glucose
The combination of protein and carbohydrate can produce greater insulin secretion than either one alone, yet high protein, moderate-to-high carbohydrate diets are very effective for weight loss
Very high carbohydrate diets have been demonstrated to produce weight loss when people are in an energy deficit
Dairy is extremely insulinemic, just as insulinemic as white bread, yet does not promote weight gain in the absence of an energy surplus. This is supported by a very large number of studies, including animal studies, observational studies, and randomized controlled trials.
Insulin is not required for fat storage
Insulin levels are not predictive of weight gain or weight loss in the majority of prospective studies
Exenatide restores rapid phase insulin release in diabetics, yet causes weight loss
The effects of insulin injection cannot be compared to normal physiological insulin release, since amylin is co-secreted with insulin from the pancreas
Insulin mainly functions as an inhibitory hormone rather than a storage hormone, acting as a brake on many important physiologic processes
A type I diabetic without insulin becomes hyperglycemic because of overproduction of glucose by the liver, not because insulin can’t get into cells
Insulin enhances the uptake of glucose into cells, but is not required for it
Insulin regulates blood sugar after a meal both by stopping the liver from producing glucose and enhancing glucose uptake into cells.
In a fasted state, insulin regulates blood sugar by controlling glucose production of the liver, not by affecting the uptake of glucose into cells
You cannot simply look at the temporary effects of insulin on lipolysis and glucose storage. You have to address what is happening over a 24-hour period; body fat will not increase if there is no overall energy surplus.

primal my ass

2010-10-11T23:10:00.000-07:00

asta a luat-o razna

parca ii si vad in pestera cum bagau un blender...

low carb diets study on mortality

2010-09-29T03:25:00.000-07:00

Low-carbohydrate diets and all-cause and cause-specific mortality: two cohort studies.

Fung TT, van Dam RM, Hankinson SE, Stampfer M, Willett WC, Hu FB.

Harvard School of Public Health, Boston, Massachusetts 02115, USA.

Comment in:

* Ann Intern Med. 2010 Sep 7;153(5):337-9.

Abstract

BACKGROUND: Data on the long-term association between low-carbohydrate diets and mortality are sparse.

OBJECTIVE: To examine the association of low-carbohydrate diets with mortality during 26 years of follow-up in women and 20 years in men.

DESIGN: Prospective cohort study of women and men who were followed from 1980 (women) or 1986 (men) until 2006. Low-carbohydrate diets, either animal-based (emphasizing animal sources of fat and protein) or vegetable-based (emphasizing vegetable sources of fat and protein), were computed from several validated food-frequency questionnaires assessed during follow-up.

SETTING: Nurses' Health Study and Health Professionals' Follow-up Study.

PARTICIPANTS: 85 168 women (aged 34 to 59 years at baseline) and 44 548 men (aged 40 to 75 years at baseline) without heart disease, cancer, or diabetes.

MEASUREMENTS: Investigators documented 12 555 deaths (2458 cardiovascular-related and 5780 cancer-related) in women and 8678 deaths (2746 cardiovascular-related and 2960 cancer-related) in men.

RESULTS: The overall low-carbohydrate score was associated with a modest increase in overall mortality in a pooled analysis (hazard ratio [HR] comparing extreme deciles, 1.12 [95% CI, 1.01 to 1.24]; P for trend = 0.136). The animal low-carbohydrate score was associated with higher all-cause mortality (pooled HR comparing extreme deciles, 1.23 [CI, 1.11 to 1.37]; P for trend = 0.051), cardiovascular mortality (corresponding HR, 1.14 [CI, 1.01 to 1.29]; P for trend = 0.029), and cancer mortality (corresponding HR, 1.28 [CI, 1.02 to 1.60]; P for trend = 0.089). In contrast, a higher vegetable low-carbohydrate score was associated with lower all-cause mortality (HR, 0.80 [CI, 0.75 to 0.85]; P for trend
LIMITATIONS: Diet and lifestyle characteristics were assessed with some degree of error. Sensitivity analyses indicated that results were probably not substantively affected by residual confounding or an unmeasured confounder. Participants were not a representative sample of the U.S. population.

CONCLUSION: A low-carbohydrate diet based on animal sources was associated with higher all-cause mortality in both men and women, whereas a vegetable-based low-carbohydrate diet was associated with lower all-cause and cardiovascular disease mortality rates.

heavy drinking saves lives

2010-09-16T01:54:00.000-07:00

cu nisate comentarii interesante ale lui Mercola

clean eatin

2010-09-14T06:44:00.001-07:00

is a SCAM

apropos de clean eating, ia uite de face dom profesor

Fitmarker

2010-09-06T08:51:00.000-07:00

un site misto

gym addiction

2010-08-10T23:46:00.000-07:00

un articol interesant

future of nutrition

2010-08-09T00:45:00.000-07:00

aici

25 iulie 2010, mamaia

2010-07-25T22:15:00.001-07:00

anorexia movie

2010-07-22T02:09:00.000-07:00

indulcitorii cu valoare calorica redusa . . . sunt ok

2010-07-20T09:40:00.001-07:00

Br J Nutr. 2010 Jul 12:1-6. [Epub ahead of print]
Sweet-taste receptors, low-energy sweeteners, glucose absorption and insulin release.

Renwick AG, Molinary SV.

School of Medicine, University of Southampton, Southampton SO17 1BJ, UK.
Abstract

The present review explores the interactions between sweeteners and enteroendocrine cells, and consequences for glucose absorption and insulin release. A combination of in vitro, in situ, molecular biology and clinical studies has formed the basis of our knowledge about the taste receptor proteins in the glucose-sensing enteroendocrine cells and the secretion of incretins by these cells. Low-energy (intense) sweeteners have been used as tools to define the role of intestinal sweet-taste receptors in glucose absorption. Recent studies using animal and human cell lines and knockout mice have shown that low-energy sweeteners can stimulate intestinal enteroendocrine cells to release glucagon-like peptide-1 and glucose-dependent insulinotropic peptide. These studies have given rise to major speculations that the ingestion of food and beverages containing low-energy sweeteners may act via these intestinal mechanisms to increase obesity and the metabolic syndrome due to a loss of equilibrium between taste receptor activation, nutrient assimilation and appetite. However, data from numerous publications on the effects of low-energy sweeteners on appetite, insulin and glucose levels, food intake and body weight have shown that there is no consistent evidence that low-energy sweeteners increase appetite or subsequent food intake, cause insulin release or affect blood pressure in normal subjects. Thus, the data from extensive in vivo studies in human subjects show that low-energy sweeteners do not have any of the adverse effects predicted by in vitro, in situ or knockout studies in animals.

Martin Berkhan Protein Muffins

2010-07-14T00:45:00.001-07:00

Protein muffins. Check out the stats on these bastards.

411 kcal
69 g protein
8.8 g fat
19 g carbs

Lots of protein. Ain't bad considering they're supposed to be pretty tasty. By popular demand, here's the recipe:

One whole extra large egg
The egg white from two extra large eggs
250 g low fat cottage cheese
33 g casein protein powder. Chocolate flavored powder was used for these.
One teaspoon bicarbonate
One teaspoon flax seed
Cinnamon
Sweetener. 1/2 deciliter, aspartame (Hermesetas). Not the liquid variety. You'll have to play this by ear depending on what sweetener you're using and how sweet you want them to be.

Mix everything together, split it up those muffin-shaped forms, and put it in the oven for 25 minutes at 150 degrees. There you go. Hope I got it right because I can't bake for shit. That's probably a good thing. Otherwise I'd be making cheesecakes all day long.

IF Debate

2010-07-12T08:07:00.001-07:00

interesant

life extension

2010-07-08T00:10:00.000-07:00

fibre

2010-07-07T12:46:00.000-07:00

insulin primer

2010-07-06T00:20:00.000-07:00

un post foarte bun

low carb metabolic advantage...not really

2010-07-05T23:36:00.000-07:00

e interesanta schimbarea de pozitie a autorului unui studiu care afirma in 2006 existenta unui avantaj metabolic al dietelor low carb (chiar keto)...aici

"Thus, the primary reason why low-carbohydrate diets tend to show superior weight loss in the short-term has nothing to do with a metabolic advantage, or an effect on insulin, or some other magical unknown effect. It all has to do with appetite control. When people consume a low-carbohydrate, high-protein diet, they are getting a “double-whammy” in regards to appetite regulation. They’re getting the dramatic benefit of increasing protein, and an additional (although smaller) benefit of a ketogenic diet. The bottom line is that the people on these diets spontaneously eat less….A LOT less.

The bottom line is that there is no metabolic advantage to a low carbohydrate intake that is independent of a high protein intake. There is a metabolic advantage to a high protein diet, which will increase the calories you burn by 80-100 calories per day. There is also a dramatic satiety advantage to a high protein intake. A low carbohydrate intake (low enough to cause ketosis) can increase this satiety advantage, but individual responses will vary. The best dietary approach for you will depend upon a variety of factors."

cum ar trebui sa faci tractiuni si de ce

2010-06-30T23:39:00.000-07:00

care oua sunt mai bune

2010-06-28T08:54:00.001-07:00

cu dedicatie pt Mr. Mechinicopshi...sau cum il cheama...

un articol aici

one benefit of fasting

2010-06-28T00:19:00.000-07:00

Autophagy. 2010 Aug 14;6(6).

Short-term fasting induces profound neuronal autophagy.
Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Abstract
Disruption of autophagy-a key homeostatic process in which cytosolic components are degraded and recycled through lysosomes-can cause neurodegeneration in tissue culture and in vivo. Upregulation of this pathway may be neuroprotective, and much effort is being invested in developing drugs that cross the blood brain barrier and increase neuronal autophagy. One well-recognized way of inducing autophagy is by food restriction, which upregulates autophagy in many organs including the liver; but current dogma holds that the brain escapes this effect, perhaps because it is a metabolically-privileged site. Here, we have re-evaluated this tenet using a novel approach that allows us to detect, enumerate and characterize autophagosomes in vivo. We first validate the approach by showing that it allows the identification and characterization of autophagosomes in the livers of food-restricted mice. We use the method to identify constitutive autophagosomes in cortical neurons and Purkinje cells, and we show that short-term fasting leads to a dramatic upregulation in neuronal autophagy. The increased neuronal autophagy is revealed by changes in autophagosome abundance and characteristics, and by diminished neuronal mTOR activity in vivo, demonstrated by a reduction in levels of phosphorylated S6 ribosomal protein in Purkinje cells. The increased abundance of autophagosomes in Purkinje cells was confirmed using transmission electron microscopy. Our data lead us to speculate that sporadic fasting might represent a simple, safe and inexpensive means to promote this potentially therapeutic neuronal response.

PMID: 20534972 [PubMed - as supplied by publisher]

Pain baby

2010-06-24T23:21:00.001-07:00

here

next trend - HIGH CARB DIET

2010-06-23T23:54:00.000-07:00

BB.com 2010 Supplement Awards

2010-06-23T01:44:00.000-07:00

and the nominees are

cel mai bun baton proteic ever

2010-06-18T05:38:00.000-07:00

Detour Bar ... unul dintre cele mai bune lucruri pe care le-am mancat vreodata

Batoanele proteice au gust de medicament si consistenta de carton presat...asta face snickers de rusine la gust

si continutul e ok...pacat ca nu se gaseste la noi...Cristi?

Prevalence of micronutrient deficiency in popular diet plans

2010-06-15T23:38:00.001-07:00

free study

summer time

2010-06-15T06:18:00.001-07:00

back pain again

2010-06-11T01:33:00.001-07:00

un post misto

heavy metal

2010-06-10T07:53:00.000-07:00

consumer report on protein powders

un site misto

2010-06-07T09:07:00.001-07:00

fitcast

o gramada de interviuri interesante

ce sa mananci/bei 2010

2010-06-04T05:13:00.000-07:00

In 2008 scriam despre ceea ce cred eu ca e ok (sau mai putin) sa mananci/bei... m-am gandit ca n-ar strica sa fac o lista revizuita:

SUPER OK: legume (cu prioritate), fructe (orice fructe, de preferat in forma lor naturala, cu coaja daca e comestibila), carne (da, si porc), peste, fructe de mare, branza (de vaci, telemea, cas, urda, cascaval, etc.), iaurt (si sana, kefir etc.), unt, oua, ulei de peste, ulei de masline, ulei de cocos, otet, condimente (fara zahar), ceai verde, apa minerala sau plata

OK: nuci (inclusiv migdale, fistic, caju etc., toate de preferat crude), soia, paine, cereale, orez, paste, batoane proteice, concentrate proteice, lapte, sucuri 100% naturale (fara adaos de zahar, de preferat si cu ceva fibre), bauturi de tip cola zero (cu indulcitori), un pahar de vin rosu (o bere neagra) pe zi, cafea

DE PRFERAT FARA: margarina, mezeluri, dulciuri (prajituri, biscuiti, ciocolata, inghetata etc.), pateuri, croissante, pizza, fast food, orice "deep fried" (gogosi, snitzele etc.), popcorn, iaurturi cu fructe, cereale cu zahar, bauturi cu zahar

observatii:

- nu exista super alimente;
- contextul si cantitatea conteaza;
- atentie la aportul caloric, in special la alimentele dense caloric (nuci, uleiuri, unt, mancaruri grase) etc.
- daca vrei sa slabesti trebuie sa consumi mai mult decat mananci; nu exista vreun aliment cu aport caloric negativ deci la regim nu adaugi alimente ca sa slabesti;
- cu cat mai putin procesat e un aliment cu atat mai bine;
- orice combinatie este ok, atata timp cat o tolerezi;
- nu e nici o problema sa mananci seara;
- nu e nici o problema sa nu mananci dimineata;
- nu ai nici un avantaj daca mananci din 3 in 3 ore; mancatul normal de 3 ori pe zi e ok;
- daca mergi la sala si faci exercitii cu greutati, e bine ca majoritatea aportului caloric din ziua respectiva sa fie dupa sala;
- daca faci cardio, macar 3-4 ore inainte nu manca nimic;
- mancarea nu trebuie sa devina o obsesie; daca mananci curat de obicei ajunge, nu trebuie sa fie totul perfect intotdeauna !

Women Power by TC from T-Mag

2010-06-03T01:40:00.001-07:00

Whether she's the live-at-home daughter of a pig farmer, a cashier at the Kwik-E-Mart, or an underwear model, most beautiful women discovered power at an early age, power in the form of sexual attractiveness, and power in the rather sad but overwhelming desire men have for their approval.

Put these two factors together, and a beautiful woman is, to most men, the most intimidating creature in the world; sort of like Freddie Krueger--same sculpted nails but with an awesome rack and a hellacious ass.

You get the sexual flip side to this when women are in the presence of a rich, powerful man. Suddenly, they're put in the same psychosexual tight wire act that men face when they're interacting with a beautiful woman.

Sure, put an ordinary woman in a room with Donald Trump and suddenly she knows how most men feel in her presence, only instead of the Donald merely firing her, men face the considerably more bleak prospect of not getting any primo ass.

Of course, if you pit a beautiful woman against a powerful man, then the power grab is nullified and they'll hook up and their spawn will wreck the remake of The Karate Kid.

For me, the intimidation comes not from the inherent power of beautiful women, but the fear of losing out on something wonderful. The nervousness I feel when I only get a few moments to lure a wünder babe into my man lair is like the nervousness a bass fisherman might feel when he's trying to land a record-setting fish, only instead of fearing you might not get your pic on the cover of Bass Master magazine, you might not get to stick your penis inside a world class hoo-hah and slide it back and forth, which, if successful, could possibly earn you the cover of Ass Master magazine.

I supposed the only way to combat this nervousness and the associated high cortisol is to, whenever in the presence of a beautiful woman, remind yourself of your inestimable talents and your self-worth. Most women can sense confidence and they're attracted to it. You have to admit, it sure beats splattering her suede pumps with urine from your nervous bladder.

If, on the other hand you don't have any talents or self-worth, you might possibly adopt a c'est la vie attitude and realize there's no reason to be nervous because there are plenty of other fish in the oil-coated sea that are already plenty drunk enough to overlook your multiple shortcomings.

ierburi eh

2010-05-27T06:53:00.000-07:00

50 cent slabeste pentru un rol...socant

2010-05-26T23:37:00.000-07:00

mai mare nu e neaparat mai atractiv

2010-05-26T01:45:00.000-07:00

GI Joe or Average Joe? The impact of average-size and muscular male fashion models on men's and women's body image and advertisement effectiveness

Phillippa C. Diedrichs ^,^a^, and Christina Lee^a

^a School of Psychology, The University of Queensland, St Lucia 4072, Australia

Received 8 December 2009;

revised 11 March 2010;

accepted 31 March 2010.

Available online 21 May 2010.

Abstract

Increasing body size and shape diversity in media imagery may promote positive body image. While research has largely focused on female models and women's body image, men may also be affected by unrealistic images. We examined the impact of average-size and muscular male fashion models on men's and women's body image and perceived advertisement effectiveness. A sample of 330 men and 289 women viewed one of four advertisement conditions: no models, muscular, average-slim or average-large models. Men and women rated average-size models as equally effective in advertisements as muscular models. For men, exposure to average-size models was associated with more positive body image in comparison to viewing no models, but no difference was found in comparison to muscular models. Similar results were found for women. Internalisation of beauty ideals did not moderate these effects. These findings suggest that average-size male models can promote positive body image and appeal to consumers.

transit time

2010-05-25T01:39:00.001-07:00

claims of weight loss supplements

2010-05-19T23:31:00.001-07:00

Claims on dietary and herbal supplements attribute weight loss to several mechanisms including the following:

* Increase of energy expenditure: ephedra, caffeine, guarana, bitter orange, yerba maté
* Increase in satiety: soluble fibers such as guar gum, glucomannan, psyllium
* Increase of fat oxidation: hydroxycitric acid (HCA), green tea, conjugated linoleic acid (CLA), fish oil, capsaicin, carnitine
* Blocking of dietary fat absorption: chitosan
* Modulation of carbohydrate metabolism: chromium
* Increase of fat excretion: calcium
* Increased water elimination: dandelion, cascara
* Enhancement of mood: St. John's wort

watch this

2010-05-18T00:07:00.001-07:00

cancer din nou

2010-05-17T05:10:00.000-07:00

un articol interesant

WTF

2010-04-30T06:13:00.001-07:00

Thailander

2010-04-29T06:14:00.000-07:00

Bradut Florescu e un tip foarte cool ..vedeti de ce aici

Blade Diet

2010-04-27T23:21:00.000-07:00

V 2.0

good read

Intermittent fasting - Martin Berkhan style

2010-04-26T00:23:00.000-07:00

Leangains Guide

cam asta fac si eu:

Two pre-workout meals

This is the usual protocol for people with normal working hours.

Sample setup

12-1 PM or around lunch/noon: Meal one. Approximately 20-25% of daily total calorie intake. (in jur de 500 kcal pentru mine)
4-5 PM: Pre-workout meal. Roughly equal to the first meal. (tot cam 500 kcal)
8-9 PM: Post-workout meal (largest meal). (cam 1.000 kcal)

mancati branza

2010-04-25T23:36:00.001-07:00

Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)¹^,2^,3

Katharina Nimptsch, Sabine Rohrmann, Rudolf Kaaks and Jakob Linseisen

¹ From the Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany (KN, SR, RK, and JL); the Department of Nutrition, Harvard School of Public Health, Boston, MA (KN); and the Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany (JL).

² Supported by ECNIS (Environmental Cancer Risk, Nutrition andIndividual Susceptibility), a network of excellence operatingwithin the European Union 6th Framework Program, Priority 5:"Food Quality and Safety" (contract no 513943).

³ Address correspondence to J Linseisen, Institute of Epidemiology,Helmholtz Zentrum München, German Research Centre for EnvironmentalHealth, Ingolstädter Landstr. 1, D-85746 Neuherberg, Germany.E-mail: j.linseisen@helmholtz-muenchen.de.

Background: Anticarcinogenic activities of vitamin K have beenobserved in animal and cell studies.

Objective: On the basis of the growth inhibitory effects ofvitamin K as observed in a variety of cancer cell lines, wehypothesized that dietary intake of phylloquinone (vitamin K₁)and menaquinones (vitamin K₂) may be associated with overallcancer incidence and mortality.

Design: In the prospective EPIC-Heidelberg (European ProspectiveInvestigation into Cancer and Nutrition–Heidelberg) cohortstudy, 24,340 participants aged 35–64 y and free of cancerat enrollment (1994–1998) were actively followed up forcancer incidence and mortality through 2008. Dietary vitaminK intake was estimated from food-frequency questionnaires completedat baseline by using HPLC-based food-composition data. Multivariate-adjustedhazard ratios (HRs) and 95% CIs were estimated by using Coxproportional hazards models.

Results: During a median follow-up time of >10 y, 1755 incidentcancer cases occurred, of which 458 were fatal. Dietary intakeof menaquinones was nonsignificantly inversely associated withoverall cancer incidence (HR for the highest compared with thelowest quartile: 0.86; 95% CI: 0.73, 1.01; P for trend = 0.08),and the association was stronger for cancer mortality (HR: 0.72;95% CI: 0.53, 0.98; P for trend = 0.03). Cancer risk reductionwith increasing intake of menaquinones was more pronounced inmen than in women, mainly driven by significant inverse associationswith prostate (P for trend = 0.03) and lung (P for trend = 0.002)cancer. We found no association with phylloquinone intake.

Conclusion: These findings suggest that dietary intake of menaquinones,which is highly determined by the consumption of cheese, isassociated with a reduced risk of incident and fatal cancer.

Bryan Haycock speaks

2010-04-21T07:59:00.001-07:00

aici

instructiv

Martin Berkham

2010-04-19T23:06:00.000-07:00

scrie un articol misto despre slabire aici

un citat elocvent:

"There’s no food that, once you eat it, flips on a metabolic switch that completely shuts down fat burning and weight loss if you’re maintaining a daily caloric deficit. It’s a question of quantity, moderation and context."

SANA GOUT

2010-04-19T05:51:00.001-07:00

Super buna mancarea Sana Gout

Lucreaza acum si la informatiile nutritionale pe care sper sa le avem in curand.

eat less / exercise more

2010-04-16T03:27:00.000-07:00

Nutr Rev. 2010 Mar;68(3):148-54.
Physical activity, food intake, and body weight regulation: insights from doubly labeled water studies.

Westerterp KR.

Department of Human Biology, Maastricht University, Maastricht, the Netherlands. k.westerterp@hb.unimaas.nl
Abstract

Body weight and energy balance can be maintained by adapting energy intake to changes in energy expenditure and vice versa, whereas short-term changes in energy expenditure are mainly caused by physical activity. This review investigates whether physical activity is affected by over- and undereating, whether intake is affected by an increase or a decrease in physical activity, and whether being overweight affects physical activity. The available evidence is based largely on studies that quantified physical activity with doubly labeled water. Overeating does not affect physical activity, while undereating decreases habitual or voluntary physical activity. Thus, it is easier to gain weight than to lose weight. An exercise-induced increase in energy requirement is typically compensated by increased energy intake, while a change to a more sedentary routine does not induce an equivalent reduction of intake and generally results in weight gain. Overweight and obese subjects tend to have similar activity energy expenditures to lean people despite being more sedentary. There are two ways in which the general population trend towards increasing body weight can be reversed: reduce intake or increase physical activity. The results of the present literature review indicate that eating less is the most effective method for preventing weight gain, despite the potential for a negative effect on physical activity when a negative energy balance is reached.

bodyfat regulation discussion

2010-04-13T23:29:00.001-07:00

aici

B&B bodybuilders

2010-04-13T06:03:00.001-07:00

un studiu nou despre satietate - mesele scurte si dese NU controleaza mai bine foamea

2010-04-12T04:26:00.000-07:00

Obesity (Silver Spring). 2010 Mar 25. [Epub ahead of print]

The Influence of Higher Protein Intake and Greater Eating Frequency on Appetite Control in Overweight and Obese Men.

Leidy HJ, Armstrong CL, Tang M, Mattes RD, Campbell WW.

[1] Department of Dietetics & Nutrition, University of Kansas Medical Center, Kansas City, Kansas, USA [2] Department of Foods & Nutrition, Ingestive Behavior Research Center, Purdue University, West Lafayette, Indiana, USA.

Abstract

The purpose of this study was to determine the effects of dietary protein intake and eating frequency on perceived appetite, satiety, and hormonal responses in overweight/obese men. Thirteen men (age 51 +/- 4 years; BMI 31.3 +/- 0.8 kg/m(2)) consumed eucaloric diets containing normal protein (79 +/- 2 g protein/day; 14% of energy intake as protein) or higher protein (138 +/- 3 g protein/day; 25% of energy intake as protein) equally divided among three eating occasions (3-EO; every 4 h) or six eating occasions (6-EO; every 2 h) on four separate days in randomized order. Hunger, fullness, plasma glucose, and hormonal responses were assessed throughout 11 h. No protein x eating frequency interactions were observed for any of the outcomes. Independent of eating frequency, higher protein led to greater daily fullness (P <>Collectively, these data suggest that higher protein intake promotes satiety and challenge the concept that increasing the number of eating occasions enhances satiety in overweight and obese men.

green tea

2010-04-11T23:38:00.001-07:00

efectele benefice ale ceaiului verde..un review aici (gratis, ca "provisional pdf")

cancer

2010-04-09T06:14:00.001-07:00

Cancer as a metabolic disease

Thomas N Seyfried and Laura M Shelton

Biology Department, Boston College, Chestnut Hill, MA 02467, USA

author email corresponding author email

Nutrition & Metabolism 2010, 7:7doi:10.1186/1743-7075-7-7

The electronic version of this article is the complete one and can be found online at:http://www.nutritionandmetabolism.com/content/7/1/7

Received:	15 November 2009
Accepted:	27 January 2010
Published:	27 January 2010

© 2010 Seyfried and Shelton; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.

Conclusions

Evidence is reviewed supporting a general hypothesis that cancer is primarily a disease of energy metabolism. All of the major hallmarks of the disease can be linked to impaired mitochondrial function. In order to maintain viability, tumor cells gradually transition to substrate level phosphorylation using glucose and glutamine as energy substrates. While cancer causing germline mutations are rare, the abundance of somatic genomic abnormalities found in the majority of cancers can arise as a secondary consequence of mitochondrial dysfunction. Once established, somatic genomic instability can contribute to further mitochondrial defects and to the metabolic inflexibility of the tumor cells. Systemic metastasis is the predicted outcome following protracted mitochondrial damage to cells of myeloid origin. Tumor cells of myeloid origin would naturally embody the capacity to exit and enter tissues. Two major conclusions emerge from the hypothesis; first that many cancers can regress if energy intake is restricted and, second, that many cancers can be prevented if energy intake is restricted. Consequently, energy restricted diets combined with drugs targeting glucose and glutamine can provide a rational strategy for the longer-term management and prevention of most cancers.

nutrigenomics - low carb vs. low fat

2010-04-09T01:41:00.000-07:00

Abstract from the recent Cardiovascular Disease Epidemiology and Prevention Conference, not been cleared for publication yet.

Genetic Phenotypes Predict Weight Loss Success: The Right Diet Does Matter
Mindy Dopler Nelson, Stanford Univ, Palo Alto, CA; Prakash Prabhakar, Venkateswarlu Kondragunta, Interleukin Genetics, Waltham, MA; Kenneth S Kornman, Interleukin Genetics, Waltham, CA; Christopher Gardner, Stanford Univ, Palo Alto, CA

Background/Introduction: Recent evidence demonstrates there is no one weight loss diet that is most effective for everyone. Genetic heterogeneity may offer a partial explanation to differential responses to different diets. Genotype patterns of single nucleotide polymorphisms (SNPs) associated with obesity and weight loss have been identified. Objective: To determine whether genotype patterns associated with macronutrient metabolism will predict weight loss success in response to low-carbohydrate vs. low-fat diets. Design: This is a secondary analysis of data from 101 Caucasian women in the A TO Z weight loss study who provided DNA from buccal cells. The analysis included diet assignments, weight loss results, and anthropometric and lipid panel values. Functional SNPs relevant to weight loss and responsive to macronutrient composition in the diet were analyzed. Women in the original A TO Z study were randomly assigned to either Atkins (very low carbohydrate), Zone (low-carbohydrate/high protein), LEARN (low-fat) or Ornish (very low fat). The subset of women was classified into 3 genotype groups; low carbohydrate diet responsive genotype (LCG, n=61) and low fat diet responsive genotype (LFG, n=35), and a balanced diet responsive genotype (BDG, n=5). Results: Participants in the appropriate dietary groups for their genotype showed 2-3 fold greater 12-month weight loss compared to participants in inappropriate dietary groups for their genotype (p=0.02) with parallel findings for reduced waist circumference (p=0.01), decreased triglycerides (p=0.007), and increased high density lipoprotein (p= 0.01). Conclusion: These findings suggest a simple DNA test of buccal cells from a cheek swab could help predict whether someone is more likely to be successful with weight loss on a low carbohydrate vs. a low fat diet.

plus un articol aici si altul aici

efedrina

2010-04-07T02:21:00.001-07:00

din categoria m-a facut mama cretin si scriu la ziar

ok, lua efedrina, si?

si eu am luat azi o pastila de aia...ar trebui sa ma tem pentru viata mea?

aspartam - safe

2010-04-05T23:56:00.001-07:00

N Z Med J. 2010 Mar 19;123(1311):53-7.
Aspartame--facts and fiction.

Magnuson B.

Senior Scientific and Regulatory Consultant, Cantox Health Sciences International, 2233 Argentia Road, Suite 308, Mississaunga, ON, Canada L5N 2X7. bmagnuson@cantox.com.

A team of nine independent internationally esteemed toxicologists, reviewed hundreds of studies on aspartame safety. The key findings of the review with respect to aspartame safety were: Aspartame is completely broken down in the intestine to components found in other foods. Aspartame consumption (even at levels much higher than consumed by the highest users) has virtually no impact on blood levels of amino acids, methanol or glucose. Aspartame safety is clearly documented and well established through extensive laboratory testing, animal experiments, human clinical trials and epidemiological (population) studies. There is no evidence from numerous well conducted studies that consumption of aspartame at levels found in the human diet are associated with conditions of nervous system, behaviour, or other illness. Aspartame does not cause mutations, and there is no credible evidence that it causes cancer.

pfff

2010-04-02T06:56:00.001-07:00

Gabriela Man, aia cu faina care slabeste, e proasta rau...da rau

Princeton fructose stupidity

2010-03-31T23:52:00.000-07:00

un articol interesant despre concluziile aberante sau cel putin pripite ale cercetatorilor de la Princeton privind efectele consumului de fructoza

Lyle - How we get fat

2010-03-26T08:27:00.000-07:00

un articol foarte bun

citatul cheie: "Fat is directly stored and carbs and protein cause you to store the fat you’re eating by decreasing fat oxidation."

cascadorii rasului

2010-03-09T07:00:00.000-08:00

cam cat de varza sunt astea

hrebe cu flacara violeta e amator...astea sunt meserie

intermittent fasting in action

2010-03-07T23:19:00.000-08:00

din cand in cand nu mananc de seara pana a doua zi la pranz sau chiar seara

14-24 de ore fara nimic caloric..doar cafea, apa, ceai

ce e interesant, si am citit ca si altii au simtit asta, este ca devin mult mai productiv, mai concentrat

plus ca imi permite sa fiu mai flexibil cu dieta in rest

2000 de kcal la o masa, la regim, da :-)

PS ma enerveaza grasutu ala de la dimineata cu razvan si dani care ne explica procesul de productie al rebuturilor de soia din "lapte de soia" dupa un proces la fel ca cel din laptele de vaca...sa mulgi tu soia pufosule

fish oil court claim

2010-03-03T05:57:00.000-08:00

aici si aici

pe scurt, se pare ca au gasit PCB in pastilele de ulei de peste de la Twinlab, Nature Made, Now Foods, Solgar, GNC ... ramane de vazut daca pot proba in instanta

REZULTATELE TESTELOR

MSG is safe

2010-02-23T09:42:00.000-08:00

sa nu ne panicam aiurea

monosodium glutamat aka MSG e ok

Independent expert panel confirms safety of Monosodium Glutamate (MSG)

An international team of experts has met to consider new evidence on the safety of the food additive, monosodium glutamate (MSG), which is used to enhance flavour in Chinese food and some processed food and beverage products. The resulting consensus was intended to replace a similar exercise published in 1997.

Experts addressed common concerns about MSG and considered relevant literature. These concerns included the likelihood of glutamate crossing the placental or blood-brain barriers, whether MSG has adverse effects on immune function or lung health, and the risks of certain consumers being sensitive to MSG.

Total intake of glutamate from food in European countries was found to be stable at between 5 to 12 g/day. New evidence on immune function was scarce. In one study, 109 people with asthma were tested after consumption of oriental food or oral glutamate to establish tolerance. No adverse reactions were noted. Two studies investigating the impact of glutamate on lung function found no effect. There was no new evidence to support the idea that specific individuals experience sensitivity to glutamate.

Turning to concerns about the metabolic fate of glutamate, the expert panel spent some time considering whether the blood brain barrier (which restricts passage of substances from the bloodstream to the brain) was vulnerable to high intakes of MSG. It was agreed that, provided the blood brain barrier was intact, passive influx of glutamate into the brain was likely to be insignificant. However, several diseases are known to impair the blood brain barrier and it can’t be ruled out that a single high dose of glutamate may have adverse effects in such cases. At present, there is no data to suggest that raised blood levels of glutamate would translate into high brain glutamate concentrations.

Data from animal studies indicate that very high concentrations of glutamate in maternal blood do not find their way across the placenta. This suggests that maternal consumption of MSG would have minimal implications for foetal development. Interestingly, breast milk in Western countries has been found to contain measurable amounts of free glutamate, increasing the likelihood that infants have a higher intake of free glutamate than they do later in life. No ill-effects of this were noted.

The expert panel regarded a dose of 16,000 mg/kg body weight (or 16 g/kg body weight) to be a safe maximum intake of MSG for adults. It was concluded that current use of glutamate salts (monosodium-L-glutamate and others) as food additives was “harmless for the whole population” and, at low doses, could help to improve appetite in the elderly.

For more information, see BeyreutherK et al (2007). Consensus meeting: monosodium glutamate – an update. European Journal of Clinical Nutrition, vol 61: pp 304-313.

cate grame de proteina la o masa

2010-02-23T04:17:00.001-08:00

un articol misto de la Alan Aragon

hardcore

2010-02-22T23:44:00.000-08:00

acum vreo 8-9 ani citeam pe testosterone.net (devenit ulterior t-nation, t-muscle, t-bullshit) ca daca nu vrei sa mergi degeaba la sala trebuie sa faci genuflexiuni cu bara in spate si indreptari

ani de zile am facut asta...genuflexiuni cu 130 de kg in spate, indreptari cu 160 de kg. rezultatul? o minunata hernie de disc, ani de zile de dureri, rmn-uri, medicamente si probabil, in final o operatie

un sfat: daca nu esti halterofil sau culturist de performanta, lasa dracu prostiile si fa niste exercitii mai sigure

body fat percentage

2010-02-21T23:45:00.000-08:00

un post interesant

diet products

2010-02-18T01:13:00.001-08:00

super funny la inceput, foarte adevarat dupa

testosterone booster supplements

2010-02-18T00:24:00.001-08:00

taxa pe fast food

2010-02-16T12:30:00.001-08:00

gerald butler...cel din 300...ce inseamna hollywood

2010-02-16T08:51:00.000-08:00

Low Carb Dogma

2010-02-15T04:23:00.000-08:00

By Jamie Hale

ISSN exercise & sports nutrition review: research & recommendations

2010-02-10T10:10:00.001-08:00

aici free

Food Inc.

2010-02-03T23:49:00.000-08:00

documentar despre industria americana de produs mancare pe banda rulanta

nominalizat la oscar in 2010 la categoria cel mai bun documentar

il puteti viziona online

dupa aia dati o fuga la micky d

lapte

2010-02-03T21:44:00.001-08:00

bun sau rau

An insulin index of foods: the insulin demand generated by 1000-kJ portions of common foods

2010-02-01T00:06:00.000-08:00

free

The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide

2010-01-31T23:55:00.000-08:00

free

no fuckin difference...low fat slightly healthier

2010-01-28T04:07:00.001-08:00

Diabetes. 2009 Dec;58(12):2741-8. Epub 2009 Aug 31.

Low-fat versus low-carbohydrate weight reduction diets: effects on weight loss, insulin resistance, and cardiovascular risk: a randomized control trial.

Bradley U, Spence M, Courtney CH, McKinley MC, Ennis CN, McCance DR, McEneny J, Bell PM, Young IS, Hunter SJ.

Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, U.K.

OBJECTIVE: Low-fat hypocaloric diets reduce insulin resistance and prevent type 2 diabetes in those at risk. Low-carbohydrate, high-fat diets are advocated as an alternative, but reciprocal increases in dietary fat may have detrimental effects on insulin resistance and offset the benefits of weight reduction. RESEARCH DESIGN AND METHODS: We investigated a low-fat (20% fat, 60% carbohydrate) versus a low-carbohydrate (60% fat, 20% carbohydrate) weight reduction diet in 24 overweight/obese subjects ([mean +/- SD] BMI 33.6 +/- 3.7 kg/m(2), aged 39 +/- 10 years) in an 8-week randomized controlled trial. All food was weighed and distributed, and intake was calculated to produce a 500 kcal/day energy deficit. Insulin action was assessed by the euglycemic clamp and insulin secretion by meal tolerance test. Body composition, adipokine levels, and vascular compliance by pulse-wave analysis were also measured. RESULTS: Significant weight loss occurred in both groups (P < p =" 0.40)." p =" 0.28)," p =" 0.71)." p =" 0.04);">, with no difference between groups (P = 0.40). Peripheral glucose uptake increased, but there was no difference between groups (P = 0.28), and suppression of endogenous glucose production was also similar between groups. Meal tolerance-related insulin secretion decreased with weight loss with no difference between groups (P = 0.71). The change in overall systemic arterial stiffness was, however, significantly different between diets (P = 0.04); this reflected a significant decrease in augmentation index following the low-fat diet, compared with a nonsignificant increase within the low-carbohydrate group. CONCLUSIONS: This study demonstrates comparable effects on insulin resistance of low-fat and low-carbohydrate diets independent of macronutrient content. The difference in augmentation index may imply a negative effect of low-carbohydrate diets on vascular risk.

PMID: 19720791 [PubMed - indexed for MEDLINE]

din nou despre relatia dintre cancer si carbohidrati

2010-01-28T00:29:00.000-08:00

un studiu nou interesant

they still don't get it

2010-01-27T01:03:00.001-08:00

eSERBAN

Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

Abstract

Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: A summary of available findings

nu din cauza insulinei esti gras

Brad Pilon - un articol interesant

Bill de Simone

Human Biological Clock

studiu nou despre post

1861 US ARMY dietary guidlines

ISSN position on meal frequency

DNA

postul religios e sanatos

slabirea este independenta de insulina

radicali liberi

Brad Pilon inflamation theory

vrei sa slabesti? poti sa mananci ORICE

mecinicumilmaicheama

American Dietary Guidlines for 2010

low carb my ass

despre celulita

insulin

twinkie diet

post intermitent (fasting)

insulin

primal my ass

low carb diets study on mortality

heavy drinking saves lives

clean eatin

Fitmarker

gym addiction

future of nutrition

25 iulie 2010, mamaia

anorexia movie

indulcitorii cu valoare calorica redusa . . . sunt ok

Martin Berkhan Protein Muffins

IF Debate

life extension

fibre

insulin primer

low carb metabolic advantage...not really

cum ar trebui sa faci tractiuni si de ce

care oua sunt mai bune

one benefit of fasting

Pain baby

next trend - HIGH CARB DIET

BB.com 2010 Supplement Awards

cel mai bun baton proteic ever

Prevalence of micronutrient deficiency in popular diet plans

summer time

back pain again

heavy metal

un site misto

ce sa mananci/bei 2010

Women Power by TC from T-Mag

ierburi eh

50 cent slabeste pentru un rol...socant

mai mare nu e neaparat mai atractiv

Abstract

transit time

claims of weight loss supplements

watch this

cancer din nou

WTF

Thailander

Blade Diet

Intermittent fasting - Martin Berkhan style

mancati branza

Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)1,2,3

Bryan Haycock speaks

Martin Berkham

SANA GOUT

eat less / exercise more

bodyfat regulation discussion

B&B bodybuilders

un studiu nou despre satietate - mesele scurte si dese NU controleaza mai bine foamea

The Influence of Higher Protein Intake and Greater Eating Frequency on Appetite Control in Overweight and Obese Men.

Abstract

green tea

Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)¹^,2^,3